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The first clinical study demonstrated that subcutaneous administration of this peptide at a dose of 0.025 mg/kg could induce visible tanning within a few dayswithout prolonged sun exposure
Lepage, B., Lamy, S., Dedieu, D., Savy, N
Regulatory status outside the US varies
Estradiol acts at the level of the cortex, hypothalamus and brainstem (14)
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