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Signal Transduct Target Ther 6:188
Similarly, 5-methoxytryptophan (5-MTP) inhibits fibroblast-to-myofibroblast transition and ECM protein expression by downregulating TGF-/Smad3 and PI3K/AKT pathways, thereby limiting fibroblast proliferation and migration [113]
Figure 2 illustrates the progression of BBB changes during the course of AD and the NP strategies specifically targeted to each disease stage
