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4.3.2 Methodological limitations and clinical strategies Existing studies generally treat pregnancy-related outcomes as secondary or exploratory endpoints and seldom report analyses stratified by weight-loss achievement, insulin-resistance improvement, or washout structure (111, 112, 124)

The SELECT trial (2023) demonstrated that Wegovy significantly reduces major adverse cardiovascular events (MACE) heart attack, stroke, cardiovascular death in patients with established cardiovascular disease and obesity

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Dr Natasha Yates, a GP and PhD candidate at Bond University, cautioned that Mounjaro was one tool in a toolkit that doctors have to help overweight patients and not a cure for obesity