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By month five or six, when most patients reach maintenance at 1.7 to 2.4 mg, the price hits the recurring rate
Enhancements in muscle tone and skin elasticity are often seen one to six months after starting therapy
Frataxin deficiency is associated with imbalances in iron-sulfur containing proteins, mitochondrial respiratory chain dysfunction and lower ATP production, and accumulation of iron in the mitochondria, which increases oxidative stress and oxidative damage to macromolecules of the respiratory chain (77)
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