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Statistical analysis The non-parametric Mann-Whitney test or Kruskal-Wallis test was used to compare the distribution of continuous variables between the different groups
This can similarly result in rapid spikes and falls in blood sugar levels, contributing to increased appetite, fatigue and a higher risk for type 2 diabetes
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doi: 10.1038/s41577-020-00478-8 249 MittalMSiddiquiMRTranKReddySPMalikAB
In the landmark study that introduced it, published in Cell Metabolism (Lee et al., 2015), researchers showed that MOTS-c regulates insulin sensitivity and metabolic homeostasis through the AMPK pathway, and that treatment prevented diet-induced obesity and insulin resistance in animal models
