The proposed downstream pathways include PI3K/Akt (neuronal survival), MAPK/ERK (cell proliferation), and Rac1/Cdc42 (actin cytoskeleton remodeling for synaptogenesis)
This helps build up the bodys Vitamin B12 stores
Concurrently, altered glucose metabolism in the orbitofrontal cortex and limbic regions reflects energy deficits and mitochondrial dysfunction, contributing to the severity of psychiatric symptoms, such as paranoia, agitation, and mood disturbances (Chang et al., 2007)
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