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Eur J Endocrinol (2012) 166(2):24753

Frequently Asked Questions Many telehealth providers use a tiered pricing structure, commonly referred to as the "dose escalation trap." When patients begin GLP-1 therapy, they start on a low initiation dose (typically 0.25 mg per week) to build tolerance

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Managing Side Effects and Finding Your Therapeutic Sweet Spot As your semaglutide dose increases, side effectsprimarily nausea, reduced appetite, and occasional constipationpeak during the first 1-2 weeks at each new dose level, then typically subside