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In people with obesity, particularly in cases of rapid or marked weight reduction, the decline in lean mass may account up to 2530% of the total weight loss, contributing to the so-called sarcopenic obesity [18]
In 1993, the first small-molecule ligands, L-692,429 and its superior derivative, L-163,191 (MK-0677), were developed, further accelerating research in this field (Table 1) (Smith et al., 1993
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