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By slowing down digestion, more gastrointestinal side effects can occur, including: Nausea Vomiting Diarrhea Constipation Bloating Indigestion Abdominal discomfort Sulfur burps (foul, rotten-egg-smelling burps) Acid reflux Why Side Effects Peak During Titration Medication can affect everyone differently, and so people may experience various side effects at different times while taking a drug, depending on their dosage and other factors