This is because tirzepatide is not just a GLP-1 receptor agonist but also a GIP receptor agonist, making it more potent in some respects and potentially more likely to cause gastrointestinal side effects in the early weeks
Research shows, that in diabetes, low-grade inflammation might trigger heightened indoleamine 2,3-dioxygenase (IDO) activity, leading to an accelerating tryptophan metabolism along the kynurenine pathway, potentially leading to serotonin deficit, that impact mood, emotional regulation, and sleep cycles (Hestad et al
whitehouse.gov (Press release)
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