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Examples of such compounds include galegine, from Galega officinalis L., the base for the synthesis of metformin and similar bisguanidine-type antidiabetic drugs, and papaverine from Papaver somniferum which is the base for making the antihypertensive drug verapamil (Fabricant and Farnsworth, 2001)

Animal studies show us that the histaminergic neurons are activated during wakefulness

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[35] In rodent pre-clinical studies, urinary and serum alpha GST have been shown to be sensitive and specific indicators of renal proximal tubular and hepatocyte necrosis respectively

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