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SURPASS-4, a multicenter open-label RCT comparing treatment with tirzepatide and insulin glargine in T2D patients at increased CV risk for a median of 85 weeks, was the only study in the SURPASS program to include the change from baseline in eGFR and UACR and occurrence of eGFR decline of at least 40%, renal death, progression to end-stage kidney disease or new-onset MA among the prespecified analyses [48]
Patient Safety Continuing appetite-suppressing medication at very low BMIs may increase the risk of: Excessive or unintended weight loss Nutritional deficiencies Lean muscle loss Hormonal disruption Disordered eating patterns The BMI 22 kg/m threshold acts as a safety boundary
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The area under the curve (AUC) is expressed as the net change in BRET ratio seconds
