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Then, the researchers administered exendin-4 via intrathecal injection to the experimental rats and observed a reduction in pain sensitivity, alleviation of neural inflammation, and suppression of inflammatory factors such as IL-1, TNF-, and iNOS
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However, long-term data on maintenance without continued cycling remains limited, and individual responses vary
In animal models, amylin signalling at the area postrema propagates to the nucleus of the solitary tract and onward to hypothalamic feeding circuits, reducing meal size and increasing the satiating effect of a given nutrient load
