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However, a recognised limitation of these therapies is that up to 40% of the weight lost may come from lean mass, which includes skeletal muscle and connective tissue

Quick dramatic changes more likely indicate inflammatory response than genuine improvement

Obviously, this ferroptosis mechanism induced by Erastin is clearly distinct from the iron overloaddriven ferroptosis observed in EMS tissues, both are based on ROS-induced lipid peroxidation and its damage to the cell membrane, leading to cell death, but the driving mechanisms differ

Protoplasma 235, 2736.10.1007/s00709-008-0026-3 69 XiangC.OliverD

Iron: the cancer connection