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The GLP-1 RA MDL has 3,848 pending actions
Patients who experience significant side effects at any dose can remain at that dose longer (6-8 weeks) before escalating, or step back to the previous dose temporarily before attempting escalation again
Borkowska etal 2007
417 Nephrotoxicity emerges as the primary adverse effect associated with lesinurad, with its incidence being dose dependent
hCG Actions: The Conceptus' Signal to the Ovary The primary role of hCG in the maternal organism is to serve as a signal to the ovary to maintain the corpus luteum, which would regress if it were not rescued by hCG
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