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despite elevated or normal GIP secretion, its insulinotropic efficacy declines
However, it isnt effective
Food and Drug Administration (FDA) approved Rybelsus for the treatment of type-2 diabetes
The structural features of DPP-IV suggest that the most likely entrance to the active site is via the large side opening ( Reference Rasmussen, Branner and Wiberg 48 )
This notion is in stark contrast to the well-known anti-diabetic properties of BAs sequestrants, (343) and some, have proven to elicit GLP-1 secretion via TGR5 mediated PC1/3 upregulation (344)
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