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This work was supported by the National Institute for Health and Care Research Maudsley Biomedical Research Centre

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Small molecules and peptide agonists of MC4R have been evaluated for obesity including MK-0493, LY2112688, MC4-NN-0453, PF-00446687 and AZD2820 and failed due to HR and BP changes, lack of human efficacy or tolerability (106)

After meals, rinse your mouth with plain water if brushing is not immediately possible

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