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These cardiovascular characterisation studies established that MT-IIs haemodynamic effects are mechanistically related to its central MC3R/MC4R activation rather than to peripheral melanocortin receptor engagement

Although we observed minimal effects on G protein recruitment with our chimeric receptors and no improvement in GIPRs arrestin recruitment with GLP-1Rs C-terminal tail, we observed significant differences in rates and extents of internalization

Melanoma of skin has increased significantly in incidence, while melanoma of oral mucosa is relatively rare

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