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This demonstrates the huge revenue driver Lilly could have through orforglipron if the drug gets approved
The cardiovascular protection offered by GLP-1 receptor agonists stems from several complementary mechanisms: Anti-inflammatory effects through suppression of CRP, TNF-, and other inflammatory markers Substantial weight reduction, particularly with higher doses of newer agents Blood pressure modulation via direct vascular effects and enhanced natriuresis Improved endothelial function and lipid profiles Renal protective effects, including reduced albuminuria and slowed eGFR decline Though initially established in type 2 diabetes populations, recent evidence from the SELECT trial confirms these benefits extend to non-diabetic patients with obesity and established cardiovascular disease
The GIP receptor activation adds an additional metabolic dimension that appears to enhance fat oxidation and improve insulin sensitivity beyond what GLP-1 activation alone achieves
The British and Irish Hypertension Society (BIHS) maintains a list of validated monitors suitable for home use
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