In study 7 , doses of CJC-1295 were escalated carefully with good tolerance, and no serious adverse events were reported in the studied dose ranges
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Patent EP1426450A1
It has been reported that suppression of EMT mediated by histone deacetylase SIRT1 gene silencing or pharmacological inhibition consequently decreases ferroptosis, which further suggests that EMT promotes ferroptosis through epigenetic regulation pathways (Lee J
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