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most mild reactions resolve without intervention Contact your GP or diabetes specialist nurse if symptoms persist beyond 72 hours or worsen Document the reaction and discuss with your healthcare provider before the next scheduled dose For moderate systemic reactions (widespread rash, mild angioedema without respiratory compromise): Discontinue the medication immediately and do not administer further doses Take an oral antihistamine promptly (note that antihistamines help with skin symptoms but are not a substitute for emergency treatment of breathing or circulation problems) Contact your GP or NHS 111 for same-day medical advice Seek urgent medical attention if symptoms progress or do not improve within 12 hours Monitor your blood glucose levels more frequently and contact your diabetes team for advice on managing your diabetes while tirzepatide is withheld, especially if you also take insulin or sulfonylureas Arrange a follow-up appointment with your prescribing clinician to discuss alternative treatment options For severe reactions or suspected anaphylaxis: Call 999 immediately for emergency medical assistance If you have been prescribed an adrenaline auto-injector (such as EpiPen, Jext, or Emerade), use it without delay according to instructions If no improvement after 5 minutes and emergency services have not arrived, administer a second dose of adrenaline if available Lie flat with legs elevated (unless breathing is difficult, in which case sit upright) Do not attempt to drive yourself to hospital Inform paramedics or emergency department staff about the tirzepatide injection and timing of administration Following any allergic reaction, it is essential to report the event to your healthcare provider and through the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk), which monitors medication safety