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Limitations of animal research: Rat healing faster than human, young research animals heal better than aged humans, controlled injury models don't replicate complex human injuries perfectly, dosing conversions uncertain (body weight scaling imperfect), immune system differences affect inflammation and healing

Brain responses to sugar: implications for alcohol use disorder and obesity

The CIP promises to capture those discoveries without the overhead of a separate patent family

Drucker, D., Easley, C

Moreover, intra-articular injection of monoiodoacetate (MIA) induces loss of articular cartilage with subchondral bone lesions that mimic those of human OA and This model offers a rapid and minimally invasive method to reproduce OA-like lesions in a rodent species [13]