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When plasma ionized calcium (Ca 2+ ) levels fall, the levels of PTH and calcitriol rise and their major sites of concerted action are bone, where they stimulate bone reabsorption, and the kidneys where they inhibit calcium excretion by stimulating reabsorption at the distal convoluted tubule and the collecting ducts

Significant changes have been recorded in glucose levels, serum insulin, HOMA-IR, CRP, and MDA following supplementation with doses of 50,000 IU of vitamin D every two weeks for 12 weeks 15