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Calzada Ltd was aggressively pursuing this treatment route in the early 2010s, reporting in 2012 that AOD-9604 might promote cartilage creation and repair [in vitro] (Source)
Clinical studies have demonstrated significant reductions in trunk fat and visceral fat specifically, with less impact on subcutaneous fat and lean mass targeting the most metabolically dangerous fat depot
Moreover, those who combine diet with intense physical activity or high-output cardio may experience increased fatigue if B12 levels are not optimal
Without human trials, every approach is an estimate
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