For example, a 2021 study found that 0.3% of the UK population (equivalent to over 200,000 people) carry a genetic mutation in part of the brain circuitry that regulates appetite, leading to an average 17kg of additional weight by age 18
Glaesner W, Vick AM, Millican R, et al
Overview of the study design to assess the comparative effects of semaglutide and tirzepatide in patients at cardiovascular risk
If sweating significantly impacts your quality of life and interferes with work, social activities, or sleep despite hydration and environmental adjustments, your provider may recommend temporary dose reduction, switching to oral semaglutide instead of injection (which achieves slightly lower peak levels), or transitioning to a different GLP-1 formulation
Medication alone is not the solution