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In contrast, plaques appeared around 6-month-old mice in APPswe/PSEN1-de9 mice employed in this study, which is similar to the APP23 model
Choi M, Park S, Lee M
It occurs at the level of gene transcription [11, 12], epigenetic regulation [13,14,15], post-translational modifications of core and accessory cell death machinery components [16,17,18], organelle-specific mechanisms [19], and organelle crosstalk [20, 21]
10.1038/srep00667 Sci Rep
We developed a sensitive, high-throughput, scalable system for profiling the cleavage activity of natural and evolved BoNT proteases on thousands of substrates simultaneously by adapting the genetic circuitry of PACE into a pooled activity-enrichment assay
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