These results provided the mechanistic foundation for developing CagriSema as a combination therapy targeting both amylin and GLP-1 pathways
Storage and handling Before reconstitution (powder) Storage : Refrigerate at 2-8C (36-46F) Shelf life : 2-3 years when properly stored Stability : Very stable as lyophilized powder Travel : Can survive room temperature for short periods (days) After reconstitution (liquid) Storage : Refrigerate immediately at 2-8C Shelf life : 28 days with bacteriostatic water Stability : Degrades over time, use within 28 days Travel : Keep cold (use cooler with ice packs) Light : Protect from direct light (store in box) Handling tips Always use clean technique Don't contaminate vial top Use new needle each time Don't freeze Don't shake vigorously Mark reconstitution date on vial Common mistakes with 5mg vials Using wrong water Mistake : Using sterile water instead of bacteriostatic water

Their compounding status under federal law is still being determined: removal from the Category 2 restricted list takes effect April 23, 2026, and the FDAs Pharmacy Compounding Advisory Committee will review whether to officially clear any of them at its July 23-24, 2026 meeting
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