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The first is that glucose-induced desensitization is due to the glucose insensibility of the -cell
IGF-1 levels are high from the fetal stage to the third decade of life
Most patients inject on the same day each week for convenience and adherence
Dehydration is a related concern, as both reduced fluid intake (due to appetite suppression) and increased fluid losses (from gastrointestinal side effects) can contribute to volume depletion
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