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Patients who stop, regain, and restart typically return to their previous lower weights with resumed treatment
Symptoms include heavy periods, breast tenderness, water retention, and mood changes
Some researchers also explore cagrilintide alongside retatrutide as a stacking strategy, though this requires careful timing coordination
In contrast, more recent research designs increasingly model fat loss and muscle preservation together, since real-world body composition outcomes rarely move on just one axis in isolation
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