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Upon activation, endothelial cells upregulate the expression of adhesion molecules, such as E-selectin and P-selectin, intercellular adhesion molecule 1 and 2 (ICAM-1 and 2), vascular cell adhesion molecule 1 (VCAM-1), and integrins, and downregulate other intercellular adhesion molecules, such as VE-Cadherin, to enhance leukocyte migration across the endothelial cell layer (9)

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Opened: approximately 28 days refrigerated

This shifts metabolic balance toward lipid dependency, establishing a lipid-driven inflammatory phenotype

A 1980 paper in Nature proposed that GHK functions by facilitating copper uptake into cells [4]