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Three 20-week double-blind, placebo-controlled studies each with 34-week extensions were conducted to evaluate the efficacy and safety of sitagliptin in 410 pediatric patients aged 10 to 17 years with inadequately controlled type 2 diabetes, with or without insulin therapy (HbA1c 6.5-10% for patients not on insulin, HbA1c 7-10% for patients on insulin)

It also aligns with the observed improvements in cardiometabolic markers seen in clinical trials of incretin-based therapies

From this perspective, ReadyRx - GLP-1 may represent cost-effective prevention compared to future medical interventions for metabolic dysfunction

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The rules have been altered before, and could well be altered again, but currently prevent more than three winners for any particular prize in any year