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Patients with pre-existing peripheral neuropathy might report changes in sensation during treatment

Pernicious anaemia , an autoimmune condition affecting intrinsic factor production in the stomach, represents the most common indication

B12 supplementation in people who are not deficient does not produce meaningful additional energy benefits beyond what normal B12 levels already provide

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Once pathological aetiologias have been discarded, it is relevant to question the supply and status of vitamins and minerals and to provide nutritional advice first aiming at promoting balanced food choices, then focusing on the use of vitamin and mineral supplementation