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It has been demonstrated that FOXO4-DRI can directly and with high affinity binds to the transactivation domain 2 (TAD2) of p53, competitively disrupting the FOXO4-p53 interaction within the nucleus
Kaitlin Ahern Author Kaitlin Ahern is a New Jerseybased health journalist and content strategist with over a decade of experience in lifestyle media and content marketing
Together, they may promote steady metabolism and cellular efficiency when supported by a healthy lifestyle
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J Clin Invest 128:35583567 Miller TM, Cudkowicz ME, Genge A et al (2022) Trial of antisense oligonucleotide Tofersen for SOD1 ALS
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