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Negative scores indicate genes whose loss reduces LDL uptake
Diagnostic translation has likewise been advanced by mitochondria-targeted probes: the 5MEF fluorescent probe demonstrates how mitochondrial accumulation and selective signal enhancement enable earlier, organelle-level detection of pathology
Evidence for the traditional inflammatory theory is as follows: tumor necrosis factor alpha (TNF-), IL-6, IL-1, IL-17, and other inflammatory cytokines involved in RA could exert pro-osteoclastogenic effects and suppress bone formation in the appropriate environment via adequate signals, such as the receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF)
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