Since they are not legal to sell for human consumption some brands sell them as research chemicals with no instructions or guidance on use other than a label
The gradual progression serves pharmacodynamic purposes beyond simple tolerability, allowing metabolic adaptations to develop fully
May relate to blood pressure effects in sensitive individuals
Edema is graded from 0 to 2, where 0 indicates no edema, 1 mild/moderate edema, and 2 severe edema
10.1007/s00125-007-0793-y Summary Keywords vitamin B 12 deficiency, hyperhomocysteinemia, type-2 diabetes, glutathione, cysteine-block Citation Karamshetty V, Acharya JD, Ghaskadbi S and Goel P (2016) Mathematical Modeling of Glutathione Status in Type 2 Diabetics with Vitamin B 12 Deficiency