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Semaglutide in adults with type 1 diabetes and obesity using automated insulin delivery
However, its structure protects it from the enzymes that usually break down GLP-1
Clinical Trial Dosing Ranges Dose Titration Schedules Clinical trials have employed gradual dose escalation to minimize gastrointestinal side effects [9] : Standard Titration Protocol (Example from ONWARDS 1) Rationale: Gradual titration allows tolerance development to gastrointestinal effects (particularly nausea) while building up to therapeutic doses
This helps the body adjust and may reduce side effects
Diabetes 6 (1), 109124
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