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Bar plots are ranked and colored by Augur score, representing cell-specific change in gene expression of the respective group relative to vehicle-treated DIO controls
Research is producing promising results, but they are currently only FDA-approved for the treatment of type 2 diabetes, sleep apnea, obesity, and obesity-related cardiovascular disease
Semaglutides mechanism of action includes slowing gastric emptying, a process that could potentially affect acid reflux
Secondary endpoints in CVOTs with GLP-1 RAs have also suggested potential kidney benefits, primarily through reductions in albuminuria, with some trials reporting a mitigation of eGFR decline [16,17,18,19, 56, 57]
Novos own combination effort, CagriSema (which combines semaglutide with cagrilintide, a mimic of both amylin and calcitonin) has produced slightly disappointing results in clinical trials
