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10.2337/diacare.22.7.1217

In Phase 3 of the TRIUMPH-4 clinical trial, Retatrutide, a triple hormone receptor agonist, produced substantial improvements in both body weight and osteoarthritis-related pain in adults with obesity

The NICE clinical guideline on the identification, assessment and management of obesity recognises GLP-1 receptor agonists, including semaglutide, as clinically appropriate interventions for adults who meet the relevant eligibility criteria, and emphasises that clinical outcomes are achieved when treatment is delivered as intended including strict adherence to administration protocols such as the fasted dosing requirement

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