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In a rat-based investigation, ergothioneine demonstrated a protective effect against cisplatininduced neuropathy and improved cognition, potentially by inhibiting oxidative stress and restoring nervous system activity

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FDA approval: AOD 9604 is not approved for any indication

NAD + is also involved in metabolic switching, or the Warburg effect, in which the main source of energy production is anaerobic glycolysis through fermentation of pyruvate to lactic acid, as opposed to mitochondrial oxidative phosphorylation 340