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Aardvark Therapeutics Sector: Oral gut-restricted bitter taste receptor agonists for hunger suppression HQ: San Diego, CA Year Founded: 2017 Origin Story: Aardvark Therapeutics was founded around a mechanistically distinct hypothesis: rather than suppressing appetite like GLP-1 drugs, the companys lead compound activates bitter taste receptors (TAS2Rs) confined to the gastrointestinal tract to trigger local release of satiety hormones, targeting hunger itself without systemic drug exposure
Our data suggest this metabolic whiplash is detrimental to heart health, Al-Aly noted
Publications mainly in alternative medicine journals not rigorous peer-reviewed mainstream journals
If FDA follows a positive PCAC recommendation and completes rulemaking, 503A pharmacies will have a legal pathway to compound these substances for individual patients
By month six (M6), 5060% achieved at least a one-point improvement across validated HS severity measures, echoing signals from earlier small case series
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