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Published Phase 2 effect sizes most prominently the ~24 percent mean body weight reduction at the 12 mg dose tier in the obesity Phase 2 (PMID 37366315) exceed those reported for dual or single agonists at comparable durations, an outcome that researchers attribute to the additional glucagon-arm contribution to body-composition and energy-expenditure pathways
Some people notice increased hunger during weeks two through four as tirzepatide continues clearing while semaglutide has not yet reached therapeutic steady state
The semaglutide transformation tends to be steady and progressive
Samuel BS, Shaito A, Motoike T, et al
Side Effects: What to Expect with Each Formulation Both injectable and oral semaglutide can cause gastrointestinal side effects, such as nausea, constipation, and diarrhea
