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It detoxifies xenobiotics and heavy metals through a reaction catalyzed by GSH S-transferases that bind them to the sulfhydryl group on the cysteine residue
First-trimester exposure to metformin and risk of birth defects: a systematic review and meta-analysis
Increased GSH synthesis neutralizes reactive oxygen and nitrogen species and regulates zinc homeostasis promoting neuroprotection after ischemia/reperfusion (162)
This PD-L1 upregulation suppresses perivascular T cell activity, impairing their ability to clear pathological signals and enabling ferroptotic mediators to accumulate and disseminate across the BBB (Kim et al., 2024)
Fact: They operate through different pathways and actually support each other by protecting and rebuilding tissues simultaneously
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