In the SURMOUNT trials, anxiety rates were actually numerically lower in the tirzepatide group compared to placebo
"Someone with a resting heart rate of 50 bpm, a high HRV, and years of training experience is often highly attuned to subtle changes in their physiology," Grosicki told me
Since muscle is a major energy utilizer 17,41 , minimizing muscle mass during caloric restriction can substantially reduce energy expenditure, thus sparing energy for the maintenance of other more critical organ systems 42,43,44
S., Anderson, K
Heres a comparison to semaglutide showing that the novel compound leads to more weight loss (blue dots are semaglutide, red dots are the new compound, black dots are placebo, and the Y-axis is body weight): Hitting different receptors may also mean an impact on tolerability - one of the big issues with these medications in the real world