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This activation involves phosphorylation and nuclear accumulation of TAp63 in oocytes, which subsequently triggers the expression of pro-apoptotic Bcl-2 family members, including PUMA, NOXA, and Bax, initiating the apoptotic pathway (Suh et al., 2006
However, a high supplement concentration can cause a minor or significant detrimental effect on the human body
A review on the cardioprotective mechanisms of metformin against doxorubicin
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