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For skin brightening, treatments are typically administered 12 times per week for the first few months, followed by maintenance sessions

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In a randomized, double-blind, placebo-controlled study, 93 subjects with colorectal polyps and 86 healthy subjects were given a placebo, folic acid (400 or 1,200 g/day), or folic acid (400 g/day) plus riboflavin (5 mg/day) for 45 days