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Skin reactions may result from: Immune-mediated hypersensitivity to the active semaglutide molecule itself Reactions to pharmaceutical excipients , particularly phenol or other preservatives Local tissue irritation from the subcutaneous injection process Formation of anti-drug antibodies , though this occurs in fewer than 1% of patients according to the EMA European Public Assessment Report (EPAR) for Ozempic Factors that may potentially increase susceptibility to Ozempic skin reactions include: Previous allergic reactions to other GLP-1 receptor agonists (such as liraglutide or dulaglutide) History of atopic conditions although evidence specifically linking atopy to increased risk of semaglutide reactions is limited Multiple drug allergies or known hypersensitivity to injectable medications Improper injection technique , such as injecting too superficially or failing to rotate injection sites Concurrent skin conditions at the injection site To minimise injection site reactions, avoid injecting into areas of infection, lipodystrophy, scars or active dermatitis

You can also contact the UK National Poisons Information Service via NHS 111 (select the poisons option), available 24 hours

This dosing schedule and route are consistent with data from the Phase 2 trial published in the New England Journal of Medicine (2023)

Key Takeaway: Feeling cold is a multi-faceted side effect caused by changes in brain signaling, the loss of physical insulation, and a natural metabolic shift during weight loss

Pain scores (measured by WOMAC) improved by up to 75.8%, with more than one in eight participants becoming completely pain-free by the end of the trial