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nevertheless, absence of controlled human trials dictates cautious, short-term use only when expected benefits outweigh fetal risks

They reflect a cascade of regenerative processes that compound over the 12 to 20 week protocol window

therefore, a sensitivity analysis was performed after excluding all cases with other AEs (retinal adverse events, acute kidney injury, hypoglycemia, nausea, vomiting, diarrhea, and pancreatitis) on the basis of model 4

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Thus, due to the nature of the original diagnostic criteria for GHD, and the reticence to consider aging a disease per se, even though disease risk, incidence and severity can be attributed at least in part to declining activity of the GH neuroendcrine axis, the criteria for determining if secretagogue therapy is indicated as an intervention in aging, are less stringent than those promulgated by Endocrine Society guidelines