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The rapid systemic clearance of unchanged metformin is solely accounted for a very extensive renal elimination by excretion into the urine, involving both glomerular filtration and active tubular secretion of this ionized hydrophilic pharmaceutical ingredient [10, 17]
B.ZempleniJ.SuttieJ
Wnt/-Catenin pathway has been recognized as one of the important pathways responsible for pattern formation during embryogenesis, and also has prominent role in cancer [91]
Usually, severe abdominal symptoms appear before there is such a fall in the blood pressure
The significant increase in total antioxidant capacity (T-AOC) together with the reduction in malonaldehyde (MDA) level, suggests a strong free radical scavenging activity associated with Spirulina supplementation
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