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Discontinuation in trials: retatrutide trial discontinuation due to adverse events was 6-10% across the higher-dose arms meaningful but lower than the dose-related side-effect profile would suggest, which indicates most participants tolerated the protocol
Neurological research has explored its effects in models of traumatic brain injury and spinal cord compression, with several studies reporting improved functional recovery versus vehicle controls
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Reassess frequently in the first weeks to catch early signs of imbalance
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