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Glutathione also enhances the effectiveness of Vitamin C, a complementary antioxidant

Regulation of ferroptosis through diverse pathways The system Xc - / GSH/ GPX4 axis The System Xc - (the cystine/glutamate antiporter system) / Glutathione (GSH) / Glutathione Peroxidase 4 (GPX4) axis, characterized by elevated GSH and GPX4 expression, represents the canonical pathway of ferroptosis

developed supramolecular prodrug nanoassemblies (SPNA) for reactive nitrogen species (RNS)-enhanced chemotherapy (Figure 3D) (Figures 3E, F), thereby generating highly toxic peroxynitrite anion (ONOO )